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Dosages of barbiturates must be individualized with total knowledge of their specific characteristics and proposed rate of administration.
The onset of motion for oral or rectal administration differs from twenty to 60 minutes. For IM administration, the onset of action is a little more rapidly. Pursuing IV administration, the onset of motion ranges from presently for pentobarbital sodium to five minutes for phenobarbital sodium.
Barbiturates could be habit forming. Tolerance, psychological and physical dependence may well happen with ongoing use. (See “Drug Abuse And Dependence” and “Pharmacokinetics” sections.) Clients that have psychological dependence on barbiturates may well improve the dosage or reduce the dosage interval without having consulting a health practitioner and should subsequently produce a physical dependence on barbiturates. To minimize the opportunity of overdosage or the development of dependence, the prescribing and dispensing of sedative-hypnotic barbiturates ought to be limited to the quantity expected for the interval until the following appointment.
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